INVESTIGATING THE ANTIBACTERIAL, ANTI- INFLAMMATORY, AND ANTIMUTAGENIC EFFECTS OF MANGO (Mangifera indica Linn) RESIN.

This study is the first investigation to evaluate the anti-inflammatory, antimutagenic, and antibacterial potential of Mangifera indica Linn resin. The anti- inflammatory activity of 50% mango resin was evaluated using the Anti-inflammatory Assay. For the antimutagenic activity, Allium cepa root tips assay was used by determining the Mitotic index and chromosomal aberrations of the cells. While for the antibacterial effect, Paper Disc Method and Pour Plate Method were used. Results showed that the 50% mango resin solution was able to impede inflammation in the mice's paw comparable to the effect of the Mefenamic Acid (P<0.05). Whereas, there was significant difference (P<0.05) between 50% resin solution and Carboxymethylcellulose. Results of the mitotic index for the antimutagenic activity showed significant difference between 50% mango resin solution and the control. While the frequency of the chromosomal aberrations showed no significant difference (P<0.05) between 50% resin solution and the control, which indicates that it could prevent unnecessary and uncontrolled cell divisions. Results also showed that 50% resin solution showed no antibacterial effect to Escherichia coli, Bacillus subtilis and Staphylococcus aureus tested.