"Blood Glucose Reduction of Annona squamosa and Capsicum frutescens Leaf Extracts and Tinospora rumphii Boerl Vine Extract on Hyperglycemic Mice (Mus mulucus)”

The Annona squamosa and Capsicum frutescens leaf extracts and Tinospora rumphii vine extract were investigated in lowering the blood glucose levels of the alloxan-induced hyperglycemic mice. A total of 15 hyperglycemic mice were administered orally by the treatments To.(distilled water), To (Glibenclamide), T_{1} (Annona squamosa), T_{2} (Capsicum frutescens) and T_{3} (Tinospora rumphii) for a period of ten days. Three blood glucose tests were conducted using a digital glucometer. Results showed that the three plant extracts possess glucose lowering effect in alloxan-induced hyperglycemic mice. A squamosa is found to be the most effective in lowering blood glucose levels, based on the percent glucose reduction obtained after 10 days of experiment. Alkaloids, tannins and flavonoids present in the extract may have be contributed to the anti-hyperglycemic activity that showed rapid neutralization of blood glucose levels in mice. Furthermore, statistical analyses reveal that the three plant extracts have antidiabetic activities comparable to that of commercially available drug. This implies that the three plants are potential sources of anti-diabetic components valuable for future pharmacological preparation of a safe, natural, effective and affordable anti-diabetic phytomedicine.